Week 3: CV Drugs 2 – Drugs for Heart Failure and Angina
Medical Pharmacology Week 3: Drugs for heart failure & angina
Contact
- Assoc Prof John Smithson John.Smithson@jcu.edu.au, and
- Robi Islam Robi.Islam@jcu.edu.au
Learning Outcomes
Be able to:
- identify the potential receptor, enzyme and ion channel targets for drugs to interact with cardiovascular function
- outline the pathophysiological mechanisms and processes responsible for the development of heart failure (HF) and angina (REVIEW)
- describe the cellular mechanism of action of drug classes used in the management of heart failure and angina
- explain the rationale for the therapeutic use for each of these drug classes in the treatment of heart failure and/or angina
- explain the major adverse effects and important interactions and contraindications associated with these drug classes
- outline the main current therapeutic approaches to pharmacotherapy of HF & stable angina.
Key Topic Descriptors
heart failure, angina, digoxin, nitrates, diuretics, ACE inhibitors, Angiotensin II receptor blockers, sartans, calcium channel blockers, beta-blockers, SGLT2 inhibitors
Preparation
This week continues our study of the drug treatment of CV disease with a focus on heart failure and angina. Many of the drug classes used in such treatment have already been discussed in the context of hypertension in week 2. The pathophysiology of HF and angina has been covered in detail in CVM last semester- make sure you review this content before the week. I will ASSUME a working knowledge of CV and renal physiology and the pathophysiology of CV disease. You will use this existing knowledge to build your understanding of the mechanisms of action of CV drugs.
Learning Resources
Readings
- Rang and Dale’s Pharmacology. 10th Ed. 2023. Chpts 20, 21, 29. (e-book available via ClinicalKey)
- Rang and Dale’s Pharmacology. 9th Ed. 2019. Chpts 22, 23, 30
- Therapeutics Guidelines – online via JCU library
- AMH – online via JCU library
- AusDI – online via JCU library
- Clinical guidelines and other resources on LearnJCU (GLS folder).